Chartered Meteorologist (CMet)
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چکیده
Accreditation as a Chartered Meteorologist (CMet) will assure clients and employers that the individual has reached, and continues to maintain, a high level of competence in their specialist areas of meteorology and has agreed to subscribe to a Code of Conduct laid down by the Society. The scheme is relevant to all professional meteorologists, whether consultants or practising professional meteorologists.
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Chartered Meteorologist (CMet)
Accreditation as a Chartered Meteorologist (CMet) will assure clients and employers that the individual has reached, and continues to maintain, a high level of competence in their specialist areas of meteorology and has agreed to subscribe to a Code of Conduct laid down by the Society. The scheme is relevant to all professional meteorologists, whether consultants or practising professional mete...
متن کاملcMET and phospho-cMET protein levels in breast cancers and survival outcomes.
PURPOSE To evaluate cMET (mesenchymal-epithelial transition factor gene) and phospho-cMET (p-cMET) levels in breast cancer subtypes and its impact on survival outcomes. EXPERIMENTAL DESIGN We measured protein levels of cMET and p-cMET in 257 breast cancers using reverse phase protein array. Regression tree method and Martingale residual plots were applied to find best cutoff point for high an...
متن کاملProgress of antibody-based inhibitors of the HGF–cMET axis in cancer therapy
Dysregulated receptor tyrosine kinase signaling in human cancer cells leads to tumor progression, invasion and metastasis. The receptor tyrosine kinase cMET is frequently overexpressed in cancer tissue, and activation of cMET signaling is related to drug resistance and the processes of carcinogenesis, invasion and metastasis. For that reason, cMET and its ligand, hepatocyte growth factor (HGF),...
متن کاملSpecific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase.
Lysosomal degradation of the receptor-tyrosine kinase cMet requires receptor ubiquitination by the E3 ubiquitin ligase Cbl followed by clathrin-dependent internalization. A role for Cbl as an adaptor for cMet internalization has been previously reported. However, the requirement for Cbl ubiquitin ligase activity in this process and its mode of recruitment to cMet has yet to be determined. Cbl c...
متن کاملNovel targeting of phospho-cMET overcomes drug resistance and induces antitumor activity in multiple myeloma.
PURPOSE The aim of the study was to verify the hypothesis that the cMet oncogene is implicated in chemio- and novel drug resistance in multiple myeloma. EXPERIMENTAL DESIGN We have evaluated the expression levels of cMET/phospho-cMET (p-cMET) and the activity of the novel selective p-cMET inhibitor (SU11274) in multiple myeloma cells, either sensitive (RPMI-8226 and MM.1S) or resistant (R5 an...
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